Καθηγητής Ελευθέριος Βαϊρακτάρης


Maxillofacial Surgery Clinic & Research Unit University Hospital "ATTIKON"

Curriculum vitae

NAME	Dr Dr MD DDS Stavros Vassiliou
DATE AND PLACE OF BIRTH	18-12-1957, Athens, Greece
EDUCATION	1969-1975 High School at Spata, Athens (Graduation July 1975) 1975-1981 University of Athens Dental School (Degree: February 1981) 1988-1993 University of Athens Medical School (Degree: October 1993)
ARMY SERVICE	Service as Dentist from 11-6-1981 to 11-6-1982
MEDICAL TRAINING, LICENSE AND CERTIFICATIONS	1985-1992 Postgraduate training as resident and fellow at the Department of Oral and Maxillofacial Surgery at “Evangelismos” Hospital in Athens 1993 License as Specialist in Oral and Maxillofacial Surgery
SCIENTIFIC CAREER	1995 Doctorate (University of Athens, Dental School): “Evaluation of ESR and platelets count alteration in patients with oral and maxillofacial cancer” 2002 Training in ATLS 2003 Doctorate (University of Athens, Medical School): “Evaluation of apoptosis in nasal and buccal cells of septic patients” 2004-present Clinical and experimental studies on the role of oncogenes and tumour suppessor genes in sequential stages of oral oncogenesis. The research is performed in animal models and in patients (record of demographic and clinical data and their association with molecular mechanisms of oral carcinogenesis).
MEMBERSHIPS	International Association of Oral and Maxillofacial Surgeons European Association for Cranio-Maxillofacial Surgery Hellenic Association of Oral and Maxillofacial Surgeons Hellenic Association of Trauma
PRESENT WORK	Senior registrar, Department of Oral and Maxillofacial Surgery, University of Athens Medical School, “Attikon” Hospital, Rimini 1, GR-12462, Greece
PUBLICATIONS	Dr Dr Vassiliou has published 59 papers and 3 chapters in scientific books, as follows:

Part A. Publications in international journals with impact factor

1. E. Vairaktaris, S. Vassiliou, C. Yapijakis, V.Papakosta, N. Kavantzas, C. Martis, E. Patsouris. Salivary gland manifestations of sarcoidosis. Report of three cases J Oral Maxillofac Surg 2005;63(7):1016–1021.

2. E. Vairaktaris, C. Yapijakis, J. Wiltfang, J. Ries, A. Vylliotis, S. Derka, S. Vassiliou, FW Neukam. Are factor V and prothrombin mutations associated with increased risk of oral cancer? Anticancer Res 2005;25(3c):2561–2565.

3. E. Vairaktaris, C. Yapijakis, P. Kessler, A. Vylliotis, J. Ries, J. Wiltfang, S. Vassiliou, S. Derka, FW Neukam. Methylenetetrahydrofolate reductase polymorphism and minor increase of risk for oral cancer. J Cancer Res Clin Oncol 2006;132(4):219–222.

4. S. Derka, E. Vairaktaris, V. Papakosta, S. Vassiliou, Y. Acil, A. Vylliotis, S. Spyridonidou, AC Lazaris, C. Mourouzis, A. Kokkori, P. Moulavasili, D. Perrea, I. Donta, C. Yapijakis, E. Patsouris. Cell proliferation and apoptosis culminate in early stages of oral oncogenesis. Oral Oncol 2006;42(5):540–550.

5. E. Vairaktaris, C. Yapijakis, S. Derka, S. Vassiliou, Z. Serefoglou, A. Vylliotis, J. Wiltfang, I. Springer, E. Nkenke, P. Kessler, FW Neukam. Association of platelet glycoprotein Ia polymorphism with minor increase of risk for oral cancer. Eur J Surg Oncol 2006;32(4):455–457.

6. E. Vairaktaris, C. Yapijakis, Z. Serefoglou, A. Vylliotis, J. Ries, E. Nkenke, J. Wiltfang, S. Derka, S. Vassiliou, I. Springer, P. Kessler, FW Neukam. Plasminogen activator inhibitor–1 polymorphism is associated with increased risk for oral cancer. Oral Oncol 2006;42(9):888–892.

7. V. Papakosta, E. Vairaktaris, A. Vylliotis, S. Derka, E. Nkenke, S. Vassiliou, A. Lazaris, C. Mourouzis, G. Rallis, S. Spyridonidou, S. Anagnostopoulou, D. Perrea, I. Donta, C. Yapijakis, E.Patsouris. The co–expression of c–myc and p53 increases and reaches a plateau early in oral oncogenesis. Anticancer Res 2006;26(4B):2957–2962

8. E. Vairaktaris, A. Yiannopoulos, A. Vylliotis, C. Yapijakis, S. Derka, S. Vassiliou, E. Nkenke, Z. Serefoglou, V. Ragos, C. Tsigris, E. Vorris, E. Critselis, D. Avgoustidis, FW Neukam, E. Patsouris. Strong association of interleukin–6 –174 G>C promoter polymorphism with increased risk for oral cancer. Int J Biol Markers 2006;21(4):246–250.

9. E. Vairaktaris, V. Ragos, C. Yapijakis, S. Derka, S. Vassiliou, E. Nkenke, A. Yannopoulos, S. Spyridonidou, A. Vylliotis, V. Papakosta, S. Loukeri, A. Lazaris, C. Tesseromatis, C. Tsigris, E. Patsouris. FGFR–2 and –3 play an important role in initial stages of oral oncogenesis. Anticancer Res 2006;26(6B):4217–4221.

10. L. Goutzanis, E.Vairaktaris, C. Yapijakis, N. Kavatzasn, E. Nkenke, S. Derka, S. Vassiliou, Y. Acil, P. Kessler, N. Stavrianeas, D. Perrea, I. Donta, P. Skandalakis, E. Patsouris. Diabetes may increase risk for oral cancer through the insulin receptor substrate–1 and focal adhesion kinase pathway. Oral Oncol 2007;43(2):165–173.

11. E. Vairaktaris, G. Papageorgiou, S. Derka, P. Moulavassili, e. Nkenke, P. Kessler, S. Vassiliou, V. Papakosta, S. Spyridonidou, A. Vylliotis, AC Lazaris, S. Anagnostopoulou, C. Mourouzis, C. Yapijakis, E. Patsouris. Expression of ets–1 is not affected by N–ras or H–ras during oral oncogenesis. J Cancer Res Clin Oncol 2007;133(4):227–233.

12. Ε. Vairaktaris, C. Yapijakis, Z. Serefoglou, S. Derka, S. Vassiliou, E. Nkenke, A. Vylliotis, J. Wiltfang, D. Avgoustidis, E. Critselis, FW Neukam, E. Patsouris. The interleukin–8 (–251A/T) polymorphism is associated with increased risk for oral squamous cell carcinoma. Eur J Surg Oncol 2007;33(4):504–507.

13. E. Vairaktaris, C. Yapijakis, A. Yiannopoulos, S. Vassiliou, Z. Serefoglou, A. vylliotis, E. Nkenke, S. Derka, E. Critselis, D. Avgoustidis, FW Neukam, E. Patsouris. Strong association of the tissue inhibitor of metalloproteinase–2 polymorphism with an increased risk of oral squamous cell carcinoma in Europeans. Oncol Rep 2007;17(4):963–968.

14. E. VairaktariS, C. Yapijakis, S. Derka, Z. Serefoglou, S. Vassiliou, E. Nkenke, V. Ragos, Α. Vylliotis, S. Spyridonidou, C. Tsigris, A. Yannopoulos, C. Tesseromatis, FW Neukam, E. Patsouris. Association of matrix metalloproteinase–1 (–1607 1G/2G) polymorphism with increased risk for oral squamous cell carcinoma. Anticancer Res 2007;27(1A):459–464.

15. E. Vairaktaris, A. Yannopoulos, S. Vassiliou, Z. Serefoglou, A. Vylliotis, E. Nkenke, E. Critselis, D. Avgoustidis, C. Yapijakis, FW Neukam, E. Patsouris. Strong association of interleukin–4 (–590 C/T) polymorphism with increased risk for oral squamous cell carcinoma in Caucasians. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;104(6):796–802.

16. E. Vairaktaris, C. Yapijakis, A. Psyrri, S. Spyridonidou, A. YANNOPOULOS, A. Lazaris, S. Vassiliou, E. Ferekidis, A. Vylliotis, E. Nkenke, E. Patsouris. Loss of tumour suppressor p16 expression in initial stages of oral oncogenesis. Anticancer Res 2007;27(2):979–984.

17. C. Yapijakis, E. Vairaktaris, S. Vassiliou, A. Vylliotis, E. Nkenke, AM Nixon, S. Derka, S. Spyridonidou, E. Vorris, FW Neukam, E. Patsouris. The low VEGF production allele of the +936C/T polymorphism is strongly associated with increased risk for oral cancer. J Cancer Res Clin Oncol 2007;133(10):787–791.

18. E. Vairaktaris, G. Kalokerinos, L. Goutzanis, S. Spyridonidou, S. Vassiliou, S. Derka, E. Nkenke, C. Yapijakis, A. Vylliotis, A. Lazaris, E. Patsouris. Diabetes alters expression of p53 and c–myc in different stages of oral oncogenesis. Anticancer Res 2007;27(3B):1465–1473.

19. E. Vairaktaris, C. Yapijakis, E. Nkenke, S. Vassiliou, A. Vylliotis, AM Nixon, S. Derka, V. Ragos, S. Spyridonidou, C. Tsigris, FW Neukam, E. Patsouris. The 1040 C/T polymorphism influencing thermal stability and activity of thrombin activatable fibrinolysis inhibitor (TAFI) is associated with risk for oral cancer. Am J Hematol 2007;82(11):1010–1012.

20. E. Vairaktaris, Z. Serefoglou, C. Yapijakis, E. nkenke, S. Vassiliou, S. Spyridonidou, A. Vylliotis, AM Nixon, FW Neukam, E. Patsouris. Coagulation–related factors Thrombomodulin and protein Z are not associated with risk for oral cancer. Anticancer Res 2007;27(4B):2449–2451.

21. E. Vairaktaris, Z. Serefoglou, C. Yapijakis, A. Vylliotis, E. Nkenke, S. Derka, S. Vassiliou, D. Avgoustidis, FW Neukam, E. Patsouris. High gene expression of matrix metalloproteinase–7 is associated with early stages of oral cancer. Anticancer Res 2007;27(4B):2493–2498.

22. E. Vairaktaris, L. Goutzanis, E. Nkenke, S. Spyridonidou, S. Vassiliou, S. Derka, A. Vylliotis, C. Yapijakis, A. Lazaris, P. Strantzias, E. Kalimeras, E. Patsouris. Expression of cell cycle regulator p16 is not affected by diabetes during oral Oncogenesis. In Vivo 2007;21(5):745–750.

23. E. Vairaktaris, L. Goutzanis, G. Kalokerinos, A. Yannopoulos, C. Yapijakis, S. Vassiliou, S. Spyridonidou, A. Vylliotis, E. Nkenke, AC Lazaris, C. Tesseromatis, E. Patsouris. Diabetes increases both N–ras and ets–1 expression during rat oral oncogenesis resulting in enhanced cell proliferation and metastatic potential. In Vivo 2007;21(4):615–621.

24. E. Vairaktaris, L. Goutzanis, E. Nkenke, S. Spyridonidou, S. Vassiliou, S. Derka, A. Vylliotis, C. Yapijakis, AC Lazaris, P. Strantzias, E. Kalimeras, E. Patsouris. Diabetes Does Not Influence Oral Oncogenesis Through Fibroblast Growth Factor Receptors. In Vivo 2007;21(4):623–628.

25. E. Vairaktaris, C. Yapijakis, C. Tsigris, S. Vassiliou, S. Derka, E. Nkenke, S. Spyridonidou, A. Vylliotis, E. Vorris, V. Ragos, FW Neukam, E. Patsouris. Association of angiotensin–converting enzyme gene insertion / deletion polymorphism with increased risk for oral cancer. Acta Oncol 2007;46(8):1097–1102.

26. E. Vairaktaris, S. Vassiliou, C. Yapijakis, S. Spyridonidou, A. Vylliotis, S. Derka, E. Nkenke, G. Fourtounis, F. Neukam, E. Patsouris. Increased risk for oral cancer is associated with coagulation factor XIII but not with factor XII. Oncol Rep 2007;18(6):1537–1543.

27. E. Vairaktaris, S. Loukeri, S. Vassiliou, E. Nkenke, S. Spyridonidou, A. Vylliotis, V. Papakosta, AC Lazaris, G. Agrogiannis, C. Yapijakis, D. Perrea, E. Patsouris. EGFR and c–Jun exhibit the same pattern of expression and increase gradually during the progress of oral oncogenesis. In Vivo 2007;21(5):791–796.

28. S. Vassiliou, C. Yapijakis, S. Derka, C. Tesseromatis, A. Psyrri, P. Antonakakis, L. Goutzanis, M. Konstadoulakis, G. Androulakis, E. Vairaktaris. Evaluation of apoptosis in nasal and buccal cells of septic patients. In Vivo 2007;21(5):901–904.

29. E. Vairaktaris, L. Goutzanis, G. Kalokerinos, S. Vassiliou, S. Spyridonidou, D. Avgoustidis, P. Stranzias, AC Lazaris, G. Papageorgiou, V. Ragos, C. Yapijakis, E. Patsouris. Increased risk for oral cancer in diabetic animals is not associated with c–jun activation pathway. J Craniomaxillofac Surg 2007;35(8):382–387.

30. E. Vairaktaris, Z. Serefoglou, C. Yapijakis, P. Stathopoulos, S. Vassiliou, S. Derka, E. Nkenke, A. Vylliotis, V. Ragos, FW Neukam, E. Patsouris. The interleukin–1 beta gene polymorphism +3953 C/T is not associated with risk for oral cancer. Anticancer Res 2007;27(6):3981–3986.

31. E. Vairaktaris, ZC Serefoglou, C. Yapijakis, A. Chatzitheofylaktou, S. Vassiliou, E. Nkenke, A. Vylliotis, S. Spyridonidou, FW Neukam, E. Patsouris. The Interleukin–18 –607A/C polymorphism is not associated with risk for oral cancer. Anticancer Res 2007;27(6):4011–4014.

32. E. Vairaktaris, C. Yapijakis, E. Nkenke, ZC Serefoglou, A. Chatzitheofylaktou, S. Vassiliou, S. Derka, A. Vylliotis, D. Perrea, FW Neukam, E. Patsouris. A metalloproteinase–13 polymorphism affecting its gene expression is associated with advanced stages of oral cancer. Anticancer Res 2007;27(6):4027–4030.

33. E. Vairaktaris, C. Yapijakis, S. Vassiliou, S. Derka, E. Nkenke, Z. Serefoglou, E. Vorris, A. Vylliotis, V. Ragos, F. Neukam, E. Patsouris. Association of –1171 promoter polymorphism of matrix metalloproteinase–3 with increased risk for oral cancer. Anticancer Res 2007;27(6):4095–4100.

34. E. Vairaktaris, ZC Serefoglou, C. Yapijakis, S. Vassiliou, E. Nkenke, D. Avgoustidis, A. Vylliotis, P. Stathopoulos, FW Neukam, E. Patrouris. The platelet glycoprotein Ibα VNTR polymorphism is associated with risk for oral cancer. Anticancer Res 2007;27(6):4121–4126.

35. E. Vairaktaris, G. Kalokerinos, L. Goutzanis, C. Yapijakis, S. Derka, S. Vassiliou, S. Spyridonidou, A. Vylliotis, E. Nkenke, AC Lazaris, E. Patsouris. Diabetes enhances cell proliferation but not Bax/Bcl–2 mediated apoptosis during oral oncogenesis. Int J Oral Maxillofac Surg 2008;37(1):60–65.

36. E. Vairaktaris, C. Yapijakis, Z. Serefoglou, S. Derka, S. Vassiliou, E. Nkenke, A. Vylliotis, S. Spyridonisou, FW Neukam, E. Patsouris. The interleukin–10 (–1082A/G) polymorphism is strongly associated with increased risk for oral squamous cell carcinoma. Anticancer Res 2008;28(1A):309–314.

37. E. Vairaktaris, A. Vylliotis, S. Spyridonidou, S. Derka, S. Vassiliou, E. Nkenke, C. Yapijakis, Z. Serefoglou, FW Neukam, E. Patsouris. A DNA polymorphism of Stromal Derived Factor–I is associated with advanced stages of oral cancer. Anticancer Res 2008;28(1Α):271–276.

38. E. Vairaktaris, S. Vassiliou, E. Nkenke, Z. Serefoglou, S. Derka, C. Tsigris, A. Vylliotis, C. Yapijakis, FW Neukam, E.Patsouris. A metalloproteinase–9 polymorphism which affects its expression is associated with increased risk for oral squamous cell carcinoma. Eur J Surg Oncol 2008;34(4):450-455.

39. E. Vairaktaris, L. Goutzanis, S. Vassiliou, S. Spyridonidou, E. Nkenke, G. Papageorgiou, P. Strantzias, AC Lazaris, C. Yapijakis, E. Patsouris. Enhancement of erbB2 and erbB3 expression during oral oncogenesis in diabetic rats. J Cancer Res Clin Oncol 2008;134(3):337-344.

40. E. Vairaktaris, C. Yapijakis, Z. Serefoglou, D. Avgoustidis, E. Critselis, S. Spyridonidou, A. Vylliotis, S. Derka, S. Vassiliou, E. Nkenke, E. Patsouris. Gene Expression Polymorphisms of Interleukins –1β, –4, –6, –8, –10, and Tumor Necrosis Factors –α, –β: Regression Analysis of their Effect upon Oral Squamous Cell Carcinoma. J Cancer Res Clin Oncol 2008;134(8):821–832.

41. E. Vairaktaris, MM Moschos, S. Vassiliou, E. Kalimeras, D. Avgoustidis, MN Moschos. Delayed Appearance of Diplopia due to Orbital Emphysema after repair of Orbital Fractures. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;106(1):e8-e10.

42. E. Vairaktaris, C. Yapijakis, A. Vylliotis, S. Derka, S. Vassiliou, E. Nkenke, Z. Serefoglou, V. Ragos, E. Critselis, D. Avgoustidis, FW Neukam, E. Patsouris. Angiotensinogen polymorphism is associated with risk for malignancy but not for oral cancer. Anticancer Res 2008;28(3A):1675 –1679.

43. E. Vairaktaris, V. Papakosta, S. Derka, S. Vassiliou, E. Nkenke, S. Spyridonidou, A. Vylliotis, AC Lazaris, A. Kokkori, P. Moulavassili, S. Loukeri, D. Perrea, I. Dontas, C. Yapijakis, E. Patsouris. H-ras and c-fos exhibit similar expression patterns during stages of oral oncogenesis. In Vivo 2008;22(5):621-628.

44. E. Vairaktaris, Z. Serefoglou, D. Avgoustidis, C. Yapijakis, E. Critselis, A. Vylliotis, S. Spyridonidou, S. Derka, S. Vassiliou, E. Nkenke, E. Patsouris. Gene polymorphisms related to angiogenesis, inflammation and thrombosis that influence risk for oral cancer. Oral Oncol. 2009; 45(3):247-253.

45. E. Vairaktaris, MM Moschos, S. Vassiliou, S. Baltatzis, E. Kalimeras, D. Avgoustiidis, MN Moschos. Orbital cellulitis, orbital subperiosteal and intraorbital abscess. Cases report and review of the literature.
J Craniomaxillofac Surg. 2009; 37(3):132-136.

46. E. Vairaktaris, L. Goutzanis, C. Yapijakis, S. Vassiliou, S. Spyridonidou, A. Vylliotis, E. Nkenke, AC Lazaris, P. Strantzias, E. Patsouris. Diabetes enhances the expression of H-ras and suppresses the expression of EGFR leading to increased cell proliferation. Histol Histopathol. 2009; 24(5):531-539.

47. C. Yapijakis, Z. Serefoglou, A. Vylliotis, E. Nkenke, S. Derka, S. Vassiliou, D. Avgoustidis, FW Neukam, E. Patsouris, E. Vairaktaris. Association of polymorphisms in Tumor Necrosis Factor Alpha and Beta genes with increased risk for oral cancer. Anticancer Res. 2009 Jun;29(6):2379-2386.

48. E. Vairaktaris, S. Vassiliou, D. Avgoustidis, P. Stathopoulos, T. Toyoshima, C. Yapijakis. Biphosphonate-induced avascular osteonecrosis of the mandible due to a common thrombophilic mutation in the prothrombin gene.
J Oral Maxillofac Surg. 2009 Sep; 67(9):2009-2012

Part B. Publications in international journals without impact factor

49. E. Vairaktaris, T.Sepheriadou, V.Ragos, T.Semergidis, S. Vassiliou. Eagle's syndrome masked by TMJ pathosis: Report of 2 cases.
Chir Testa e Collo 1994;11:69–75.

50. E. Vairaktaris, P. Moulavassili, S. Loukeri, S. Spyridonidou, C. Yapijakis, S. Vassiliou, E. Nkenke, A. Vylliotis, V. Papakosta, AC Lazaris, E. Patsouris. Abundance and localization of skeletal muscle–related erbB2 may stimulate tumour growth during initial stages of oral oncogenesis. J Musculoskeletal Neuronal Interact 2007;7(2):185–190.

51. T. Sepheriadou, S. Vassiliou, K. Villias, K. Petraki. Leiοmyosarcoma melastatic to the oral region. Second Volumetto Estrato da 2nd Mediterranean Congress of Oral and Maxillofacial Surgery 1993: 207-212.

Part C. Publications in Greek scientific journals

52. S. Vassiliou, E. Stavrou, S. Kamberos , Chr. Martis. Oral and maxillofacial surgery in children with endocrinologic disease. Paedodontia 1988; 3(3,4):183-187

53. A. Sklavounos, E. Stavrou, S. Vassiliou, Chr. Martis. Intraoral pleomorphic adenoma. Syn Odondiatros 1989; 9(1): 37-42.

54. E. Stavrou, Chr. Martis, S. Vassiliou. Fracture of the styloid process. Greek J Oral Max Fac S 1989; 4: 47-48.

55. E. Stavrou, S. Vassiliou, S. Kamberos. Indications and Contraindications of the Administration of Antibiotics in Oral and Maxillofacial Surgery. Hellenic Stomatological Review 1989; 33(3): 185-189.

56. E. Eleftheriadis, E. Angelopoulou. S. Vassiliou, S. Sotiriadou, Chr. Martis. Aneurysmal bone cyst of the mandible. Report of case. . Hellenic Stomatological Review 1991; 6: 31-34.

57. Chr Samaras, S. Vassiliou, E. Eleftheriadis, Th. Sepheriadou. A study of surgically treated patients with impacted teeth. Hellenic Stomatological Review 1992; 36: 209-215.

58. E. Vairaktaris, S. Vassiliou, I. Iatrou, V. Ragos, Th. Sepheriadou. Treatment results evaluation in patients with cancer of the oral region. Greek J Oral Max Fac S 1993; 8: 93-99.

59. E. Vairaktaris, Th. Semergidis, I. Iatrou, D. Papaioannou, S. Vassiliou, Chr. Martis. Mucoepidermoid carcinoma of salivary glands: surgical treatment of 6 cases. Greek J Oral Max Fac S 1993; 8: 37-45.

Part D. Chapters in Books

1. E. Vairaktaris, S. Vassiliou, G. Rallis. The Maxillofacial surgical patient. Preoperative evaluation and postoperative complications. In G. Androulakis. Perioperative care. Chapter 30, p. 355-397, Athens 2001.

2. E. Vairaktaris, S. Vassiliou, N. Schwenzer. Clefts lip-alveolar-palate. Clinical presentation and histopathology. In E. Vairaktaris, N. Schwenzer, FW. Neukam. Oral and Maxillofacial Surgery. Trauma – Craniofacial Dysplasiae, Chapter 8, p. 343-374, Athens 2005.

3. E. Vairaktaris, S. Vassiliou, N. Schwenzer. Primary reconstruction of clefts. In E. Vairaktaris, N. Schwenzer, FW. Neukam. Oral and Maxillofacial Surgery. Trauma – Craniofacial Dysplasiae, Chapter 9, p. 375-478, Athens 2005.

Maxillofacial Surgery Clinic & Research Unit University Hospital "ATTIKON"